

Primary Hyperoxaluria
A genetic disorder in which kidney stones give reason to investigate further
Warning Signs of Primary Hyperoxaluria (PH)
If your patient is experiencing one or more of the following symptoms, primary hyperoxaluria, also known as PH, may be the cause.1-7
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Understanding Primary Hyperoxaluria
PH is a family of rare genetic disorders causing hepatic oxalate overproduction that can result in life-threatening kidney damage. Although PH1 is the most well known, all PH subtypes are likely underdiagnosed.8,9
Mechanism of Disease
Although PH primarily manifests as a kidney disease, it originates with an enzyme deficiency in the liver. This enzyme deficiency results in a buildup of glyoxylate, which is converted to oxalate by hepatic LDH.8,10

Diagnosing Primary Hyperoxaluria
Many patients with primary hyperoxaluria experience a significant delay in diagnosis. The diagnostic process typically begins with a 24-hour urine test. Genetic testing can confirm a PH diagnosis and subtype.1,8,11-13

Managing Primary Hyperoxaluria
PH1, PH2, and PH3 are all linked to kidney stones and burdensome stone removal procedures, with 70% of patients requiring one or more urologic procedures during their lifetime. In more advanced cases, PH patients may require regular dialysis and a dual liver-kidney transplant.8,14-24
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