Mechanism of Disease

ROLE OF HEPATIC LDH

Converting a Nonharmful Substance Into a Disease-Causing Agent Through Hepatic Lactate Dehydrogenase (LDH)

See what causes primary hyperoxaluria (PH) by watching the video below.

In the glyoxylate metabolic pathway, glyoxylate is normally recycled by a number of different enzymes in the hepatocyte.1,2

Normal Glyoxylate Metabolic Pathway1,2

Graphic showing the normal glyoxylate metabolic pathway in liver cells. Graphic showing the normal glyoxylate metabolic pathway in liver cells.
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In the 3 genetically defined subtypes of PH, a defect in 1 of 3 liver enzymes causes a deficiency in the glyoxylate metabolic pathway, resulting in the overproduction of glyoxylate.1-6

Dysregulated Glyoxylate Metabolic Pathway1

Graphic showing the dysregulated glyoxylate metabolic pathway in liver cells for PH1, PH2, and PH3. Graphic showing the dysregulated glyoxylate metabolic pathway in liver cells for PH1, PH2, and PH3.
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Graphic showing the dysregulated glyoxylate metabolic pathway in liver cells for PH1, PH2, and PH3. - Continued Graphic showing the dysregulated glyoxylate metabolic pathway in liver cells for PH1, PH2, and PH3. - Continued

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