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ROLE OF HEPATIC LDH
Converting a Nonharmful Substance Into a Disease-Causing Agent Through Hepatic Lactate Dehydrogenase (LDH)
See what causes primary hyperoxaluria (PH) by watching the video below.
In the glyoxylate metabolic pathway, glyoxylate is normally recycled by a number of different enzymes in the hepatocyte.1,2
Normal Glyoxylate Metabolic Pathway1,2
In the 3 genetically defined subtypes of PH, a defect in 1 of 3 liver enzymes causes a deficiency in the glyoxylate metabolic pathway, resulting in the overproduction of glyoxylate.1-6
Dysregulated Glyoxylate Metabolic Pathway1
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